Design and synthesis of novel Cdc25A-inhibitors having phosphate group as a hydrophilic residue

Rumiko Shimazawa; Mika Gochomori; Ryuichi Shirai

doi:10.1016/j.bmcl.2004.05.083

Design and synthesis of novel Cdc25A-inhibitors having phosphate group as a hydrophilic residue

Bioorg Med Chem Lett. 2004 Aug 16;14(16):4339-42. doi: 10.1016/j.bmcl.2004.05.083.

Authors

Rumiko Shimazawa¹, Mika Gochomori, Ryuichi Shirai

Affiliation

¹ Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

PMID: 15261298
DOI: 10.1016/j.bmcl.2004.05.083

Abstract

Compounds (6a-e) were synthesized by phosphorylation of hydrophobic perhydroindan derivatives derived from vitamin D(3), and were found to show strong inhibitory activity towards dual-specificity phosphatase Cdc25A (IC(50)=0.7-24.5 microM).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / pharmacology
Phosphates / chemistry*
cdc25 Phosphatases / antagonists & inhibitors*

Substances

Enzyme Inhibitors
Phosphates
cdc25 Phosphatases